0710国际期刊速递丨今日热点西洛他
TODAY今日发布TheJournalofClinicalHypertensionEarlyRecent,July09,今日发布06篇（共计05篇）JournalofCardiacSurgeryEarlyRecent,July09,今日发布06篇（共计01篇）CATHETERCARDIOINTEEarlyRecent,July09,今日发布01篇EBioMedicineEarlyRecent,July09,今日发布01篇TheLancetJuly11,:(),71-今日发布27篇ESCHeartFailureEarlyRecent,July10,今日发布01篇StrokeEarlyRecent,July10,今日发布16篇EClinicalMedicineEarlyRecent,July10,今日发布01篇EchocardiographyEarlyRecent,July10,今日发布01篇RECOMMEND推荐阅读01西洛他唑对脑卒中和认知功能减退的二级预防作用Strokeresearch-articleCarolineMcHutchison,GordonW.Blair,etc.2小时前等50用户推荐阅读本文BackgroundandPurpose:Cilostazol,aphosphodiesterase3’inhibitor,isusedinAsia-Pacificcountriesforstrokeprevention,butrarelyusedelsewhere.Inadditiontoweakantiplateleteffects,itstabilizesendothelium,aidsmyelinrepairandastrocyte-neuronenergytransferinlaboratorymodels,effectsthatmaybebeneficialinpreventingsmallvesseldiseaseprogression.西洛他唑是一种磷酸二酯酶3抑制剂，在亚太国家用于预防中风，但在其他地方很少使用。除了微弱的抗血小板作用外，它还能稳定内皮，帮助髓鞘修复和实验模型中的星形胶质细胞神经元能量转移，这些作用可能有助于防止小血管疾病的进展。Methods:Asystematicreviewandmeta-analysisofunconfoundedrandomizedcontrolledtrialsofcilostazoltopreventstroke,cognitivedecline,orradiologicalsmallvesseldiseaselesionprogression.Tworeviewerssearchedforpapers(January1,toJuly16,)andextracteddata.WecalculatedPetooddsratios(ORs)and95%CIsforrecurrentischemic,hemorrhagicstroke,death,adversesymptoms,withsensitivityanalyses.Thereviewisregistered(CRD).西洛他唑预防脑卒中、认知功能下降或放射性小血管病变进展的系统回顾和荟萃分析。两名评论员搜索论文（年1月1日至年7月16日）并提取数据。通过敏感性分析，我们计算了复发性缺血性中风、出血性中风、死亡、不良症状的Peto优势比（ORs）和95%可信区间。审查已登记（CRD）。Results:Weincluded20randomizedcontrolledtrials(n=10?),18inischemicstroke(totaln=10?)and2incognitiveimpairment(n=56);mostwereperformedinAsia-Pacificcountries.Cilostazoldecreasedrecurrentischemicstroke(17trials,n=10?,OR=0.68[95%CI,0.57–0.81];P0.),hemorrhagicstroke(16trials,n=,OR=0.43[95%CI,0.29–0.64];P=0.),deaths(OR=0.64[95%CI,0.49–0.83],P0.),systemicbleeding(n=,OR=0.73[95%CI,0.54–0.99];P=0.04),butincreasedheadacheandpalpitations,
